International Conference on the Great Manchurian Plague: A Pioneering Blueprint for Public Health Advances and Safeguards

International Relations, Medical history, Public health,, Regional History

Once the authorities in Manchuria had secured a firm handle on the plague outbreak in Heilongjiang, Kirin and Fengtian provinces by February 1911, little time was wasted calling for a conference of international medical specialists to enquire into all aspects of the epidemic and promote the advancement of future disease control. Scientists including disease specialists from many countries were invited to attend the location chosen for the conference, Mukden (Shenyang), which was one of the cities in North-East China hardest hit by the pneumonic epidemic.

B1888135-B036-4C07-9615-30CB41114CBEDespite the pressingly urgent need to canvas expert international input into the dire health catastrophe, China must have had some reservations about what it was doing. Both Russia and Japan with undisguised Manchurian ambitions already held firm footholds in N.E. China (control over railway lines, ports, territorial concessions, etc), plus other Western powers controlled Chinese treaty ports further south. But with no politicians taking part in the conference and all attendees pledging that it’s focus was to be on scientific investigation and not about imposing any further external controls on China, the central government pushed on with it [‘In 1911, another epidemic swept through China. That time, the world came together’, (Paul French), CNN, 19-Apr-2020, www.cnn.com]. Dr Wu Lien-teh, the “plague fighter-general” of Harbin, was appointed conference chairperson. There were a few “nationalistic frictions” with the Japanese mainly resulting from some anti-Chinese remarks injudiciously made by the Japanese delegate, Professor Kitasato, before leaving Tokyo for the conference, but this did not impede the cohesion of the conference  [Eli Chernin (1989). “Richard Pearson Strong and the Manchurian Epidemic of Pneumonic Plague, 1910—1911” (PDF)Journal of the History of Medicine and Allied Sciences. 44(3): 296–319. doi:101093/jhmas/44.3.296PMID 2671146].

🔻 Safety precautions at Harbin plague site

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A congress of international disease experts
The International Plague Conference (IPC) was a ground-breaking series of ‘firsts’, the first international scientific symposium held in China, the first time in modern history of a multi-nation approach focusing on disease control. The conference also anticipated the purpose of later world bodies dedicated to international health maintenance, the League of Nations’ Health Organisation (LNHO), established in 1923, and  it’s successor, the UN’s World Health Organisation (WHO), created after the Second World War.

3A6D176E-BB45-4C08-B823-02421AA93931Scientists from ten countries joined host China at the Plague Conference in the repurposed Shao Ho Yien palace – the US, UK, France, Russia, Japan, Italy, Germany, Austro-Hungary, Netherlands and Mexico, an indication of how seriously the international medical community took the Manchurian outbreak and its implications. The delegates were drawn from several relevant and related fields including epidemiologists, virologists, bacteriologists, tropical medicine specialists and illness consultants.

🔻 Contemporary coverage of the conference in ‘The Lancet’

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The conference, getting into the “nitty-gritty’ 
High on the conference’s agenda was the question of aetiology, what were the Great Manchurian Plague’s causal factors? American delegate Richard P Strong, who arrived prior to the conference, undertook pathological experimentation which verified the infectious role played by tarbagan marmots in the plague (which he published in the Philippine Journal of Science, 1912). The experts had to sift through a raft of unhelpful faux-scientific beliefs and assumptions to get to “the scientific root of the bacteria”, again underlining the IPC’s emphasis on science and medicine. Containment was another key issue at the conference. The discussion was around what worked best in the plague? Measures like ‘blanket’ quarantines, travel bans, face masks and ad hoc plague hospitals (swiftly assembled to isolate the infected from the healthy), all got a big tick…an endorsement of Dr Wu Lien-teh’s positive measures in the war against the pneumonic epidemic, deemed by the conference delegates as essential tools in the fight against future outbreaks and waves of plague (French).

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🔺 The admirable Dr Wu

Seeds of a nationwide public health service 
One of the conference’s finest and far-reaching achievements was to establish the Manchurian Plague Prevention Service (under the helm of Dr Wu). The MPPS and Wu identified medical education as the “holy grail”, the service’s role was to  disseminate materials to the public, promote the efficacy of sanitary conditions and health in the community, and overall playing a leading role in adopting Western medicine (Xīyào) and methods of disease control in China. MPPS provided the model for a future Chinese national health service (French).

The follow-up to the three-and-a-half week International Plague Conference put Chinese medicine on the path to modernisation. Many of the country’s medical advances began here …. the IPC laid down a blueprint for handling future plagues which included the use of autopsies,  instructional dissection and cremation, all of which became institutionalised practice afterwards (Chernin).

Medicine and health before politics
The Mukden IPC in April 1911, conducted in an atmosphere free of politicising, demonstrated the cooperative humanitarian efforts of a group of medical professionals…when left to it by the politicians, they showed single-minded unity of purpose, what could be achieved, collectively and internationally, to counter the danger of a disease with immediate and future global ramifications for public health. I need not emphasise the stark contrast with the management of the world’s current pandemic in which some of the major powers, distracted from the only really important priority, are happy to engage in a ”political blame game” over the coronavirus‘ origins, instead of co-operating with each other to meet a pernicious and deadly health risk to the planet head-on and in unison.
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Endnote: Lessening future shock
The gains in medicine and public health protection coming out of the conference were soon put to use in China. Disease re-emerged in the 1919 malaria epidemic and the 1921 plague (again in Harbin) which was to test China’s embryonic national quarantine system. Dr Wu again took charge to guide China through these medical crises. The improvements in public health since 1911, it is estimated, reduced casualties in the second outbreak of pneumatic plague by four-fifths [‘Portraits of a plague: the 19th-century pandemic that killed 12 million people’, History Extra, 21-Jul-2015, www.historyextra.com].

Manchuria 1910-1911: North-East China’s End of Empire Frontier Plague

International Relations, Medical history, Political geography, Public health,, Regional History

In 1910 the 265 year-old Qing Dynasty in China was fasting approaching its denouement. The following year it would be deposed and replaced with a republic. Over the years leading up to this point, Imperial China had been in long drawn-out decline, suffering a series of reversals – a disastrous defeat in the (1st) Sino-Japanese War (1894-95) and ensuing loss of territorial sovereignty in Manchuria; the crushing of the Peking Boxer Rebellion in 1900. In 1907 China had been beset by the latest (and one of the worst) of a series of famines (“Third Plague Pandemic”), losing an estimated 25 million of it’s population. And in late 1910, Manchuria in the midst of a tense political situation—China having to share the region with competing Russian and Japanese aspirations—a plague broke out.

FDA0880F-AA83-4106-9454-5939A414DD1AThe plague was first noticed in the Inner Mongolian town of Manzhouli on the Chinese-Russian border, where Russian doctors began treating patients with fever and haemoptysis symptoms. Thus began the Great Manchurian Plague which eventually took up to 60,000 lives in less than six months – with a mortality rate very close to 100 per cent [William C Summers, The Great Manchurian Plague: The Geopolitics of an Epidemic Disease, (2012)].

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Vector from the rodent family
Because of a past pattern of bubonic plague in China, rats and fleas were initially suspected to be the source of human infection.  50,000 rats were examined but the results proved negative [CHERNIN, ELI. “Richard Pearson Strong and the Manchurian Epidemic of Pneumonic Plague, 1910–1911.” Journal of the History of Medicine and Allied Sciences, vol. 44, no. 3, 1989, pp. 296–319. JSTOR, www.jstor.org/stable/24633015. Accessed 5 May 2020]. The disease was eventually traced to the Siberian marmot (Marmota sibirica) or tarbagan, found in Inner Mongolia, eastern Siberia and Heilongjiang. Later research by Dr Wu (see below) and others established that the plague, like the present coronavirus, was pneumonic, transmitted animal to human by respiratory droplets, and not bubonic.

A roaring trade in fake mink
The European fashion for mink and ermine furs can be ‘fingered’ for being at the bottom of the preconditions leading to the 1910 plague. Mink’s popularity as one of the most prized materials for clothing accessories made it’s cost prohibitive to all but the richest Europeans. Things changed when it was discovered that the fur of the marmot when dyed passed very convincingly for mink fur. After the pelt price for marmot fur soared from 12 cents to 72 cents a hide, hordes of Chinese hunters from the central provinces swarmed into the region to join the lucrative hunt for the now in-demand creature. Mongol and Buryat hunters, long experienced in marmot-hunting knew how to select only tarbagan marmots which were not diseased for culling. The inexperienced Chinese trappers however didn’t practice safe hunting methods, failing to discern the difference, they hunted marmots indiscriminately. Thus, the infection was passed on to humans from the pelts of the disease-ridden rodents (Chernin; ‘Manchurian Plague 1910-11’, (Summers; Iain Meiklejohn), Disasterhistory.org, (April 2020), www.disasterhistory.org].

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Spreading the plague by rail
Manchuria at the time was equipped with an extensive network of railroads, thanks to the vested interests of the Russians and the Japanese which the Qing Dynasty had, reluctantly, conceded. Russia controlled the Trans-Siberian Railway (TSR) and the China Eastern Railway (CER), Japan controlled the Southern Manchurian Railway (SMR). The time of the year was an important factor. From November/December, as the weather turned arctic-like, the Chinese hunters and agricultural migrant workers started to return to their home regions. The foremost consideration was to get back before the Chinese New Year. The hunters and the labourers, huddled together infecting each other  in the bitter cold of the train carriages, carried the plague along the railway lines. In a short time the plague travelled from its origin point to large cities on the Dongbei line, Harbin, including the central district of Fuchiatien (Fujiandian), Changchun and Mukden (today Shenyang). Compare this to what happened with the coronavirus outbreak which spread from Wuhan to other Chinese cities by airplane.

5EC44B3F-9EA7-477C-8AE9-C2BFEEE17955In the disease’s wake mortality proceeded at an alarming rate, Harbin in the far north was the initial epicentre. In November 5,272 died in the city. It then spread along the tracks to cities further south, Mukden recorded a death toll of 2,571 by January 1911, and Changchun was losing over 200 a day to the plague (Meiklejohn). The plague was sustained and promoted by the prevailing conditions it encountered – dense population, high human mobility and poor hygiene environments (Cornelia Knab, cited in Meiklejohn). Eventually the plague reached Peking and as far as central China.

Enter Dr Wu
The authorities, in desperation, turned to a migrant, Penang-born doctor working at the time in Tianjin, Wu Lien-Teh. Cambridge-educated Wu took immediate charge of the medical emergency in Harbin. Enforcing a strict quarantine in the city, Wu put in place a series of comprehensive measures to contain the disease, including:

● converting railway freight cars to makeshift quarantine centres and turning a bathing establishment into a plague hospital

● establishing “sanitary zones” in the city

● closing down the railways in Manchuria, impose blockades, border controls and so stop infected people from travelling (Wu needed to secure the co-operation of the Russian and Japanese rail companies to achieve this)

● burning the lodgings of those infected

● monitoring the population by checking households for new cases

● advocating the wearing of face masks (Wu had more effective masks with extra gauze padding made)

● carrying out mass cremations of the infected dead (considered a sacrilege in Chinese society, Wu had to petition the emperor for permission)

● undertaking post-mortem examinations of the victims (again, a Chinese taboo that Wu had to overcome objections to)✲

Temperature check, Fuchiatien 
(www.Flickr.com)

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With no vaccine for pneumatic plague available, Wu’s quarantine measures involved isolating people for a five to ten day period, if no symptoms present, they are released with a wire band attached to their wrist signifying they have been cleared of the disease [‘In 1911, another epidemic swept through China. That time, the world came together’, (Paul French), CNN, 19-Apr-2020, www.cnn.com; ‘The Chinese Doctor Who Beat the Plague’, (Jeremiah Jenne), China Channel, 20-Dec-2018, www.chinachannel.org].

 

 Old plague hospital, Harbin. When the epidemic was suppressed, the hospital was burnt down to eliminate any residual risk of contamination  

 

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(Photowww.avezink.livejournal.com)

Keeping the ports plague-free
The concerted efforts of Japanese, Russian and Chinese managed to prevent the epidemic from reaching the eastern seaboard. Several towns close to the major port city Dalian reported cases, but Dalian itself (by this time under Japanese control, known as Dairen), initially undertook mass inspections of train and ship passengers, before closing the South Manchurian line altogether. With such strictures in place Dalian was wholly spared from the plague (French).  The Russians were able to similarly stem the outbreak’s movement along the CER rail line and stop it from reaching Russia’s vital Pacific port, Vladivostok.

Racing against catastrophe
What added even more pressure to Wu’s task in trying to control the plague was that he was working against a tight deadline. The plague needed to be contained before 30th January which was Chinese New Year’s Eve. Thousands of migrant workers would be returning home to their families for this most important annual celebrations in China via the Manchurian railway network, which Wu knew would make it almost impossible to rein in the outbreak. The conscientious and thorough measures implemented in northern China made it possible for Wu to be able to declare the epidemic virtually suppressed by the end of January. Decisive action in N.E. China also prevented the plague from spreading to near-by (Outer) Mongolia and Russian Siberia. By March all the region’s shops, factories and schools were reopened and the only lingering infection was confined within the specially established plague hospitals (Meiklejohn).

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Endnote: Dr Wu 
Many Chinese medical personnel including epidemiologists and other physicians contributed to preventing the plague spreading throughout China, and to suppressing it all together within a short period. But if anyone should be called a hero of the Great Manchurian Plague of 1910-11, certainly that mantle should land on Dr Wu Lien-Teh, whose decisive leadership, organisation and enterprise saved China’s North-East provinces from a much higher casualty toll and from the regional plague developing into a nationwide epidemic.

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 China for it’s part controlled the Imperial Railways of North China, which linked Peking with Mukden
 one case was recorded in Shanghai, 2,000 miles away
 thousands of bodies were still above ground in coffins because the relatives were waiting for the spring thaw to bury the dead…ideal incubators for the plague bacillus to magnify the contamination [‘Dr Wu Lien-Teh, plague fighter and father of the Chinese public health system’, (Zhongliang Ma & Yanli Li), www.ncbi.nim.nih.gov; Jenne)
✲ Wu performed the first autopsy in Harbin, identifying the disease as the bacterium Yersinia pestis of the pneumonic variant [‘Wu Lieh-Teh: Malaysia’s little-known plague virus fighter’, Star Online, 11-Feb-2020, www.msn.com]

Pandemic Pastimes: Armchair Epidemiology 101 – Curiouser and Curiouser

Medical history, Popular Culture, Public health,, Science and society, Sport

BC48FDE2-4DF8-4771-9E1B-C1F7C0F2963CFor most of us the coronavirus crisis is, if not all-consuming, at the front and centre of just about everything at the moment. This pandemic, this pandemocracy, is all over social media, and one of the most curious by-products is how the emergence of this novel virus has spawned a novel social media and sociological phenomena called the armchair epidemiologist… instant experts with their own special take on how COVID-19 should be handled, what it’s all really about, the whole thing de-mystified and unravelled in a nutshell. As you will see below, it is unfortunate at this pivotal moment that the practice of responsible social distancing hasn’t always been matched by the practice of responsible social media distancing.

29CD1A1A-6CD9-403A-B9C0-DA10957DA4D9Why is armchair epidemiology a burgeoning sub-industry at the moment? One general explanation lies in the character of the pandemic itself. It’s a troubling time right across the globe, people are naturally anxious about the disease—especially if you are unlucky enough to be living in a country that is one of the major hotspots at the moment—so talking about it can be a calming mechanism of sorts, working it all out in your head so it makes sense. As Noah Feldman neatly puts it, “one way for humans to cope with anxiety is to seek rational mastery over observable phenomena”. This becomes doubly the case in this situation because of the nature of this particular ‘beast’. The lack of “concrete empirical data” on the disease, the shortcomings in the science as it stands now, means that even amongst the genuine experts, uncertainty reigns (‘Will the Armchair Coronavirus Experts Please Sit Down’, Noah Feldman, Bloomberg: Opinion, 25-Mar-2020).  The experts have disagreed over which is the correct strategy to follow in the fight to contain the virus, what works, what doesn’t, full lockdowns, “let it rip” herd immunity, whether or not to use face masks, etc. Add to this the questionable way some countries have handled their outbreaks—eg, the slowness of for instance Italy, the US and Britain to take decisive steps in the early phase of the pandemic—the result, a critical failure to get on top of COVID-19 before the curve took off on it’s rapid skyward trajectory. Into this void the amateur epidemiologists have been only too happy to step.

BBFEF828-0542-42ED-992E-8C9D7E26485FOf course another reason for the house-bound commentariat directing it’s focus and energies towards the COVID-19 debate, could be sheer boredom. There’s only so much time on any given ‘Groundhog’ day you can spend bingeing on modish, ”must see” television series before you start to suffer mental fatigue and withdrawal symptoms.

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(Image: www.rfclipart.com)

Another explanation of Feldman’s that I am taken with is armchair epidemiology expert as a substitute for armchair sport expert. The suburban “Weekend Norms” of the world ritually delight in analysing the games of football and other sports they watch on the ‘box’ and on Fox,  but courtesy of the pandemic the sporting calendar is denuded, the presence of live sport on our screens is already a fading memory. The average punter, Feldman suggests, may simply, by necessity, have switched from analysing sport to analysing the coronavirus phenomena (the only game in town!).

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(Image: www.geneticliteracyproject.org)

Some observers of the armchair epidemiology contagion have noted an element of the Dunning-Kruger Effect at work here – “a cognitive bias in which people overestimate their knowledge or ability in a specific domain” (‘Psychology Today’). This contends that someone’s legitimate expertise in another field “gives them a false sense that their speculation and predictive powers are more informed” than the general person…and thus in this time of global upheaval, they don’t hold back in telling everyone  (‘Elon Musk is the Ultimate Armchair Epidemiologist’, Alex Lauer, Inside Hook, 01-May-2020, www.insidehook.com). Tim Requarth’s example are certain Silicon Valley “data wonks” who have produced “superficially convincing but flawed epidemiological analyses” and “sweeping predictions” of the pandemic to arrive at a conclusion that the emergency restrictions are an overreaction, contradicting the advice of public health experts. The criticism of much of the amateur epidemiology indulged in by non-public health professionals is that they tend to throw data round randomly, get the basic principles skew-whiff and make faulty assumptions. Spare us from the “good intentions” of a plague of DK-19 experts!  (‘Please, Let’s Stop the Epidemic of Armchair Epidemiology’, Tim Requarth, Slate, 26-Mar-2020, www.slate.com).

 

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 or perhaps, like President Trump, they just don’t trust experts, medical or otherwise
 described by one cynic as “people lacking the ability to understand their lack of ability”

 

Not Missing the Human Touch: Robots Stepping Up in the Time of COVID-19

Medical history, Public health,, Science and society

 

Intelligent design, AI, artificial humanoids, bionic life, androids, cyborgs, have all moved outside of the cloistered environment of the lab and the science fiction genre and are all embracing the day-to-day functions of human existence. Well, perhaps not all of these products of imagination and creativity – but with the restrictions placed on human communication in the all–enveloping cloud of the coronavirus crisis, automatons are the new “white knights” coming to the rescue (or relief) of humans.

The sudden emergence of the pandemic has propelled Medtech companies into the war on COVID-19. Drones as well as robots are being enlisted in the fight, taking the load off medical professionals and health care systems. Delivery robots are used as a way of circumventing the danger of human-to-human contagion. UVD robots are employed to kill viruses and bacteria in rooms to avoid the need for human involvement [‘Robots And Drones Are Now Used To Fight COVID-19’, (Bernard Marr), Forbes, 18-Mar-2020, www.forbes.com].

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‘Xenex’ Germ-zapping robots (CBS News)

As healthcare experts and governments search for the optimum strategy to contain and suppress the coronavirus outbreak, other intelligent humans are finding new applications and roles for intelligent non-humans in the health emergency crisis. It starts, appropriately enough for a public health disaster, at the medical coal face, in the ICU wards where doctors and nurses have been overwhelmed, physically and emotionally, with the skyrocketing workload of coronavirus-affected patients. In Lombardy in northern Italy, one of the first hotspots of the pandemic outside of China, six robot nurses have been fast-tracked into hospital service in Varese where they help lighten the human nurses’ face-to-face load and reduce their risk of personal infection. The robots man the wards, monitor the medical equipment and communicate remotely with doctors. Similarly in India, at a hospital in Chennai, ‘Zafi’ the robot does the rounds, transporting food and medicine to virus patients to lessen the risk to hospital medical staff [‘Tommy the robot nurse helps keep Italian doctors safe from coronavirus’, (Flavio LoScalzo), Reuters, 02-Apr-2020, www.reuters.com].

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Pepper the robot  (Photo: Reuters)

Japan is using humanoid robots as reception staff at hotels to greet patients with mild coronavirus symptoms. Robots like ‘Pepper’ at Kyogoku in Tokyo greet arriving patients and instruct them how to check-in while reassuring them with warm and positive messages [‘Pepper the robot set to greet COVID-19 patients checking in Tokyo hotels’, Hindustan Times, 01-May-2020, www.hidustantimes.com].

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With the need for pristine clean surfaces in public spaces to prevent the spread of the virus outbreak, a number of countries now employ robots as cleaners. At Hong Kong International Airport autonomous cleaning robots known as “Intelligent Sterilisation Robots” use UV light and air sterilisers to routinely clean and disinfect key operational areas of the airport [‘Clean me up, Scotty: Hong Kong airport debuts cleaning robots, disinfection booth in fight against COVID-19’, Coconuts, 30-Apr-2020, www.msn.com].

Such medical uses of robots have been replicated across a range of countries hit by the pandemic. With people confined to their homes under quarantine orders and required to maintain a distance of at least 150 cm from other humans, robots on wheels are being increasingly used to deliver products to them, or to deliver food to overworked NHS workers (Britain).

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(Photo: www.uk.news.yahoo.com)

Singapore has brought into service a robot with the decidedly unsexy name of “O-R3”, whose job it is to patrol the city’s parks and monitor the behaviour of joggers. This ever vigilant robot spots transgressors and warns them about the need to practice social distancing in public [‘Robot in Singapore tells joggers to stay home’, SBS, 28-Apr-2020, www.sbs.com.au]. Joggers and walkers in Singapore need to ultra-alert around the parks as the city has a second social distancing-monitor robot, Boston-built Spot the robotic dog (Robocop?)…if O-R3 doesn’t nap the violators, Spot (below) might.

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(Photo: CNA)

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Tunisia’s ‘Robocop’ looks more like a military style armoured vehicle  
(Photo: AFP)

Tunisian authorities have had a similar idea to curtail the incidence of virus infection in the capital Tunis. The police have been using a robot (a ‘Robocop’) who ‘walks’ the city beats, stopping and questioning people who it suspects should not be on the streets during lockdown. The Robocop asks people to produce their IDs which can be scanned by the robot’s in-built computer [‘Coronavirus: Tunisia deploys police robot on lockdown patrol’, (Rana Jawad), BBC News, (03-Apr-2020), www.bbcnews.com].

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Robot Cop (Source: The Hindu)

Chennai Police (southern India) are on the same wavelength as Tunis’, deploying it’s new “Robot Cop LD v5.0” equipped with a two-way intercom to surveil citizens in coronavirus hotspots in the city during containment. The Robot Cop is un-humanoid in appearance and has been described as “an oversized box on wheels” [‘Chennai Police Deploys “Robot Cop” in COVID-19 Hotspot’, (Kishalaya Kundu), Beebom, 01-May-2020, www.beebom.com].

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(Photo: BBT University)

Robotic engineers in Japan have produced avatar robots who can stand in for university graduands in virtual graduation ceremonies. BBT University in Tokyo uses ‘newme’ robots dressed in black graduation gowns and caps with mobile screens showing the student’s face attached to a motherboard. The robot proxies line up to be officially presented with a testamur by the university president while the actual graduate watches via Zoom from a safe distance at home [‘BBT University in Japan has graduates attend ceremonies via robots in light of Covid-19’, (Guan Zhen Tan), Mothership, 02-Apr-2020, www.mothership.sg].